Associate Principal Scientist, Regenerative Immunology

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ICR's Regenerative Immunology program is focused on regenerating the aging immune system, the decline of which underlies many of the most devastating age-related diseases. We're hiring a Principal Scientist to lead our Thymic Regeneration Team to restore thymic function and rejuvenate adaptive immunity. You'll need a deep background in immunology, thymic biology and iPSCs. 

With ICR, you'll get to:

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• Lead a cutting-edge team developing iPSC-derived thymic epithelial cells (iTECs) and thymic organoids to rejuvenate the aging immune system
• Contribute highly practical and readily translatable thymic regeneration, immune reconstitution and rejuvenative medicine ideas
• Design and optimize directed-differentiation protocols to generate functional, TECs from human iPSCs
• Collaborate with other ICR scientists and groups to advance immune rejuvenation under a personalized medicine paradigm

Please apply if you have:

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• A PhD or MD/PhD
• At least 10 years of research experience, preferably in thymic biology, stem cell differentiation, organoid engineering or regenerative immunology
• Current and in-depth knowledge of thymic epithelial cell biology, iPSC directed differentiation, T-cell development and tissue engineering
• Expert knowledge in experimental therapeutics and the landscape of developmental pipelines of practical, actionable interventions to treat and prevent age-related immune senescence and achieve immune regeneration/rejuvenation

Ideally, you'll also have:

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• Expert knowledge of thymic epithelial cell ontogeny, FOXN1 biology, T-cell selection and thymic niche reconstitution
• Experience with iPSC culture, directed differentiation, 3D organoid culture, single-cell genomics, RNAseq, flow cytometry, immunofluorescent microscopy, CRISPR gene editing and cell culture
• Experience with in vivo transplantation, humanized mouse models and assessment of functional immune reconstitution
• Even if you don't meet all of these criteria, please apply anyway

And you'll need:‍

• A friendly, easygoing personality
• The ability to work in the United States without sponsorship

Starting base pay range: $160,000/yr - $215,000/yr

Starting additional compensation range: $10,000/yr - $20,000/yr

Starting position title and compensation are commensurate with experience.