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Connective tissues and the extracellular matrices of cells like fibroblasts hold our bodies together, contribute to systemic and organ failure with age, yet remain underappreciated in the field of aging biology. We take multiple approaches to understand why connective tissues fail with age and how to repair and regenerate them. 

The need to repair the aging extracellular matrix (ECM) is an underappreciated aspect of modern regenerative medicine research. ICR is recruiting for a scientist with experience in human ECM biology and the motivation to create interventions that can repair aging ECM.